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tTMB-P7(6.83) Reference Standard

CBP80001-7

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I. Background

Tumor mutational burden (TMB) shows great promise as a biomarker for immuno-oncology (I-O) therapy response, but progress is hindered by the lack of a standardized TMB measurement by targeted NGS panels, and an absence of TMB reference materials.

 

Sample ID

Cat.No.

Background

Assay

Comments

DC198N0157

CBP80001-7N

B lymphoblast, Female

500x WES

Same individual

 

DC198N0156

CBP80001-7T

Ductal breast carcinoma, Female

500x WES

IDT xGenExome Research Panel v1.0捕獲,Target Region 39M, Probe Region 51M,CDS Region 33.52M;
HiSeq X-TEN,af選擇0.02 cut off,再過濾。
DC198N0156 is 100% Tumor sample.

 

 

Cut off =2%

Cut off =3%

Cut off =4%

Cut off =5%

Mutation Number

229

218

208

201

TMB value

6.83

6.50

6.21

6.00 

 

計算數(shù)據(jù)下載:DC198N0156.tmb

 
 
 
 
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